Axenfeld-Rieger Anomaly (ARA) and Axenfeld-Rieger Syndrome (ARS): for professionals Axenfeld-Reiger anomaly is a form of anterior segment dysgenesis with increased risk of glaucoma development. The main ocular feature is posterior embryotoxon. Other features include iris and pupil abnormalities. Axenfeld-Reiger syndrome is ARA with dental defect, craniofacial anomalies and redundant periumbilical skin.