Overview Dominant optic atrophy References Overview Gene (OMIM No.) OPA1 (#605290) Function of gene/protein Protein: mitochondrial dynamin like GTPase Inner...

Dominant optic atrophy is the commonest form of inherited optic neruopathies, with majority of the cases associated with autosomal dominant OPA1 mutations. Patients tend to present with bilateral progressive painless visual loss without spontaneous recovery. About 20% of patients also have neurological symptoms, with sensorineural hearing loss being the most common.

Dominant optic atrophy is an inherited condition that leads to progressive degeneration of the optic nerve. Patients tend to develop visual loss in both eyes around childhood or teenage years which gradually worsens.