Aniridia is a a pan-ocular bilateral congenital eye anomaly characterised by complete or partial iris hypoplasia, foveal hypoplasia and early-onset nystagmus. Patients with WT1 deletion are at risk of developing Wilms tumour.

MAC represents a spectrum of congenital ocular developmental defects that accounts for roughly 20% of childhood visual impairment. It is usually associated with other ocular abnormalities and systemic features.