Aniridia is a rare birth eye defect characterised by an under-developed or absent iris (no eye colour). It can be associated with WAGR syndrome, increasing the risk of developing Wilms tumour.

Aniridia is a a pan-ocular bilateral congenital eye anomaly characterised by complete or partial iris hypoplasia, foveal hypoplasia and early-onset nystagmus. Patients with WT1 deletion are at risk of developing Wilms tumour.

WAGR is a condition that affects multiple body systems. Its main features are Wilms tumour, aniridia, genitourinary abnormalities and range of developmental delays.

WAGR syndrome describes its four main features: Wilms tumour, aniridia, genitourinary anomalies and range of developmental delays. It is due to deletion of chromosome 11p13.

Overview Aniridia WAGR syndrome Anterior segment dysgenesis Microphthalmia, anophthalmia, coloboma (MAC) Additional information Clinical images References Overview Gene (OMIM No.)...